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calendar   Monday - August 17, 2020

Flowers For Algernon?

Leftist InstaHate For COVID Flower Cure

because Trump mentioned it

image

Funny, I kind of thought it was the President’s job to keep people aware of new possibilities and to give them even temporary hope. But the Left may be right on this one. Like the blind squirrel ...

Most Americans have been praying for a cure to the Chinese Communist Party virus. Such a prospect turns out to be horrifying, however, if you are a Deep State bureaucrat, someone invested in open-ended and lucrative research into unpromising medicines or vaccines and/or a political opponent of President Trump.

Hence the vehemently hostile response of a leftist publication called Axios to information about Oleandrin, a natural supplement that has proven in clinical experiments and limited human trials in Texas to crush the CCP virus. Rather than celebrate this development and call for an urgent effort to validate such findings with widespread, life-saving trials, Axios touted the uninformed criticisms of naysayers determined to snuff further work on this apparent breakthrough.

To the alarm of some government health officials, President Trump has expressed enthusiasm for the Food and Drug Administration to permit an extract from the oleander plant to be marketed as a dietary supplement or, alternatively, approved as a drug to cure COVID-19, despite lack of proof that it works.

Driving the news: The experimental botanical extract, oleandrin, was promoted to Trump during an Oval Office meeting in July. It’s embraced by Housing and Urban Development Secretary Ben Carson and MyPillow founder and CEO Mike Lindell, a big Trump backer, who recently took a financial stake in the company that develops the product.

OMG, if Mike Lindell is behind it, you know it’s deathly anathema.

Oleandrin is an extract from the oleander plant. Researchers have suggested that it could be useful to treat cancer because of the way it affects cells, and that it could enhance the effects of other cancer therapies.

Professor Sharon Lewin, the director of the Peter Doherty Institute for Infection and Immunity at the University of Melbourne, is an international authority on antiviral drugs and has a laboratory working on COVID-19.
Asked about oleandrin’s potential efficacy as a COVID-19 treatment, Lewin told Axios, “Oleandrin looks to have antiviral activity at high doses in a test tube model. You’d certainly want to see more work done on this before even contemplating a human trial.”

A July 2020 study from the University of Texas at Galveston shows, in a laboratory setting, that oleandrin can inhibit the coronavirus in monkey kidney cells. This study has not been peer reviewed and one of the authors of the study, Robert Newman, is chairman of Phoenix Biotechnology’s scientific advisory board — the company developing the oleandrin product.

The bottom line: Scientists around the world are in a race for cures, treatments and vaccines for COVID-19. Government regulators are investigating hundreds of products. When a biotech executive like Whitney can take his case directly to the president, it casts doubt over the scientific rigor of the drug development process.

From the research study:

Using Vero cells, we found that prophylactic oleandrin administration at concentrations down to 0.05 μg/ml exhibited potent antiviral activity against SARS-CoV-2, with an 800 fold reduction in virus production, and a 0.1 μg/ml dose resulted in a greater than 3,000-fold reduction in infectious virus production. The EC50values were 11.98ng/ml when virus output was measured at 24 hours post-infection, and 7.07ng/ml measured at 48 hours post-infection. Therapeutic (post-infection) treatment up to 24 hours after infection of Vero cells also reduced viral titers, with the 0.1 μg/ml dose causing greater than 100-foldreductions as measured at 48 hours, and the 0.05 μg/ml dose resulting in a 3578-fold reduction.The potent prophylactic and therapeutic antiviral activities demonstrated here strongly support the further development of oleandrin to reduce the severity of COVID-19 and potentially also to reduce spread by persons diagnosed early after infection.

In years past the FDA has been dinged for major slow walking and foot dragging when it comes to testing and approving new medicines. Many drugs are available to the rest of the world that are not yet available to us. With this pandemic that slowness has become an issue, but I don’t think the best idea is to throw caution to the wind and let anything fly. That way leads to snake oil. There has to be some level of significant proper, fair, testing.

OTOH, the Axios article does mention how this could easily be marketed as an herbal supplement, which could NOT focus on any curative ability. To which there’s an easy work around; “We’re NOT ALLOWED to mention that this cures Covid, and thus cannot recommend a dose of 2 pills a day for 2 weeks. This product is for dietary supplemental use only, and we bear no responsibility for it’s use in any other manner.” kind of advertising.

OTTH, shouldn’t President Trump know by now when to keep his fat mouth shut?



BIG FAT WARNING FROM MEMORIAL SLOAN KETTERING:
Oleandir is poisonous !!! !! !

Consumption of even one Nerium oleander leaf can be fatal. Onset of toxicity occurs several hours following consumption. Symptoms include vomiting, abdominal pain, cyanosis, hypotension, hypothermia, vertigo, respiratory paralysis and death.

However, a carefully controlled tea made from the flowers could be an effective cancer and AIDS treatment. But more trials are needed!!

A hot water extract of the plant, known as Anvirzel™, has been developed as a potential treatment for cancer, AIDS, and congestive heart failure. It consists of a mixture of oleandrin and the glycone oleandrigenin. Experiments suggest that a combination of Anvirzel and cisplatin may be more effective than cisplatin monotherapy . In an earlier study, Anvirzel appeared safe in humans when injected intramuscularly, although adverse effects such as injection site pain, fatigue, and other GI symptoms were reported.

Anvirzel™ is not an approved cancer treatment in the United States. Until more data regarding its efficacy and toxicity are available, this product should not be used outside of clinical trials.

Anvirzel may be a modern version of a medicinal extract of oleander that goes back to the dawn of history.

Historical records prove that Oleander plant has healing powers; thus it was highly regarded by the Mesopotamians in the 15th century B.C. During the age of the Babylonians up to the Romans it was used as a relieved for hangovers. To the Arabs it has better worth since the plant was used for cancer medication in the 8th century A.D.

OTOH, the Romans also used it to commit suicide.

I looked up the entry at Wiki ... and I think I’ll pass on this one. There may be too much risk in a cure made from just a little bit of deadly poison.


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Posted by Drew458   United States  on 08/17/2020 at 01:06 PM   
Filed Under: • pandemic and epidemic diseases •  
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