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calendar   Tuesday - March 17, 2020

A glimmer of hope? Or mabye 3 of them?

Inexpensive readily available malaria pills may prevent/slow/cure COVID-19

HIV meds might do the job too, or work with the malarial for a stronger curative

UPDATE: Chloroquine is actually Hydroxychloroquine, the same as hyrodxychloroquine sulfate, and is the common drug called Plaquenil or Quinprox. Aside from being a malaria treatment, Plaquenil is used to treat lupus and rheumatoid arthritis. Extremely high doses can mess up your eyesight, causing retinopathy.

[ news today: ] Recent guidelines from South Korea and China report that chloroquine is an effective antiviral therapeutic treatment against Coronavirus Disease 2019.  Use of chloroquine (tablets) is showing favorable outcomes in humans infected with Coronavirus including faster time to recovery and shorter hospital stay.  US CDC research shows that chloroquine also has strong potential as a prophylactic (preventative) measure against coronavirus in the lab, while we wait for a vaccine to be developed.  Chloroquine is an inexpensive, globally available drug that has been in widespread human use since 1945 against malaria, autoimmune and various other conditions. 

“Data from the drug’s [chloroquine] studies showed ‘certain curative effect’ with ‘fairly good efficacy’ … patients treated with chloroquine demonstrated a better drop in fever, improvement of lung CT images, and required a shorter time to recover compared to parallel groups.  The percentage of patients with negative viral nucleic acid tests was also higher with the anti-malarial drug… Chloroquine has so far shown no obvious serious adverse reactions in more than 100 participants in the trials… Chloroquine was selected after several screening rounds of thousands of existing drugs.  Chloroquine is undergoing further trials in more than ten hospitals in Beijing, Guangdong province and Hunnan province.”

~~~~

[ China, exactly one month ago: ] Three potential anti-COVID19 medicines have been officially announced by the Ministry of Science and Technology: Favilavir [Fapilavir], Chloroquine Phosphate, and Remdesivir. They all initially showed more obvious curative effects and lower adverse reactions in clinical trials.
...
The other one with the most potential – so far – has been Remdesivir, which Gilead had already been developing as a treatment for Ebola disease and Marbug virus infections. It has subsequently also been found to show antiviral activity against other single-stranded RNA viruses such as respiratory syncytial virus, Junin virus, Lassa fever virus, Nipah virus, Hendra virus, and coronaviruses (including MERS and SARS viruses).

~~~~

[ Australia today: ] Queensland researchers find ‘cure’, want drug trial

Some patients who tested positive for coronavirus in Australia have already been treated with one of the drugs and “all did very, very well,” researchers say.
...
A team of Australian researchers say they’ve found a cure for the novel coronavirus and hope to have patients enrolled in a nationwide trial by the end of the month.

University of Queensland Centre for Clinical Research director Professor David Paterson told news.com.au today they have seen two drugs used to treat other conditions wipe out the virus in test tubes.

He said one of the medications, given to some of the first people to test positive for COVID-19 in Australia, had already resulted in “disappearance of the virus” and complete recovery from the infection.

Prof Paterson, who is also an infectious disease physician at the Royal Brisbane and Women’s Hospital, said it wasn’t a stretch to label the drugs “a treatment or a cure”.

“It’s a potentially effective treatment,” he said.

“Patients would end up with no viable coronavirus in their system at all after the end of therapy.”

The drugs are both already registered and available in Australia.
...
One of the two medications is a HIV drug, which has been superseded by “newer generation” HIV drugs, and the other is an anti-malaria drug called chloroquine which is rarely used and “kept on the shelf now” due to resistance to malaria.

He said the researchers want to study them in a “very meaningful way” against the coronavirus to “try and alleviate that anxiety of Australians”.


I’ve got an idea for a clinical trial: at least 180,000 people wordwide have this bug. There are millions of doses of malaria pills sitting around everywhere. A whole bottle of pills is under $10. I say go for it.

It may also be the case that cholorquine works better with the HIV drugs, which I guarantee cost a whole lot more than a mosquito pills that’s been around since the 1940s.

And then there’s the zinc supplement thing, and the selenium supplement thing, and the vitamin C supplement thing. And I’ve read that South Korea and Japan are getting good results using some pancreatitis medicine that is not FDA approved yet.

On the third hand, absolute authoritarian lockdowns seem to have done the job in China. But they aren’t saying whether or not they’re feeding the entire country choloroquine tablets.

[ 2/6/20 China trying Remdesivir: ] Doctors in Washington State gave remdesivir to the first coronavirus patient in the United States last week after his condition worsened and pneumonia developed when he’d been in the hospital for a week. His symptoms improved the next day.

A single case cannot determine whether a drug works, but a report on the Washington patient, in The New England Journal of Medicine, has nonetheless sparked excitement about the drug.

Another report published on Tuesday by scientists in China added to the enthusiasm, showing that remdesivir blocked the new coronavirus, officially known as 2019-nCoV, from infecting cells grown in the lab.

...

Gilead had stockpiled the drug, as well as the materials used to make it, for use against Ebola. The company is now using that stockpile for the trials in China and for individual patients like the one in Washington State




Remdesivir may also work against kitty cat coronavirus, which is a whole different thing.

More links to studies that say the same thing:
https://www.nature.com/articles/s41422-020-0282-0
https://www.ncbi.nlm.nih.gov/pubmed/32164085
https://www.ncbi.nlm.nih.gov/pubmed/15351731
https://www.healthline.com/health/coronavirus-treatment#potential-treatments
https://www.pharmaceutical-technology.com/comment/parallel-export-covid-19/


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Posted by Drew458   United States  on 03/17/2020 at 08:41 AM   
Filed Under: • Health-Medicinepandemic and epidemic diseases •  
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Oh, and here's some kind of visitor flag counter thingy. Hey, all the cool blogs have one, so I should too. The Visitors Online thingy up at the top doesn't count anything, but it looks neat. It had better, since I paid actual money for it.
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