Wednesday - April 08, 2020

It’s A Floor Wax AND A Dessert Topping

2500 French Cancer Patients Take Methylene Blue. Not One Gets COVID

Methelyne Blue is THE original synthetic medicine and was the first malaria drug back in 1891. It has been used to treat urinary tract infections (and turns your pee blue), has strong antiviral properties, was used to treat psychiatric patients and lead to the development of thorazine, and is used to dye samples for microscope slides. And it’s a fish tank cleaner.

Ok, just like Chloroquine Phosphate, it’s actually an aquarium medicine, but everybody is saying fish tank cleaner, so be it. It kills the fungus in the tank, and the slime on your fish, so close enough.

Oh, and chloroguine is made from methelyne blue. So there ya go.

Here’s another one of those “purely anecdotal” reports:

We report the case of a cohort of 2500 French patients treated among others with methylene blue for cancer care. During the COVID-19 epidemics none of them developed influenza-like illness. Albeit this lack of infection might be by chance alone, it is possible that methylene blue might have a preventive effect for COVID-19 infection. This is in line with the antiviral activity of Chloroquine, a Methylene blue derivative.

Both Chloroquine and Methylene blue have strong antiviral and anti- inflammatory properties probably linked to the change in intracellular pH and redox state.

Europe has been recently been hit by an epidemic of COVID-19. We report a cohort of patients treated for cancer in France. This cohort is managed by an association (Espoir Metabolique) and is a cancer support group. There are 2500 patients all at high risk for sepsis because of concomitant chemotherapy. One of us has interviewed (by telephone and by e mail) these patients to register the cases of COVID-19. As of March 27th, 2020, there were no cases of registered COVID-19 or of flu–like syndroms. These patients were treated by a combination of standard therapy and α-lipoic acid (800 mg twice a day), hydroxycitrate (500 mg three times a day) and methylene blue (75 mg three times a day) as well as a low carb diet.

Patients were also being treated with hydroxycitrate, which is a derivative of citric acid, commonly known as Vitamin C. Lipoic acid is made by most animals, and is needed for aerobic metabolism.

Cancer is another kind of disease able to lead to cytokines storms and one may expect a large number of deaths from COVID-19 in such patients. However, our survey among our database of patients treated with a combination of α-lipoic acid, hydroxycitrate and methylene blue suggests that this treatment prevents from severe infection from COVID-19. It may thus be anticipated, but yet not proved, that MB⊕ could be of considerable help for fighting against the COVID-19 epidemics. Here, we give a survey of the very interesting properties of this molecule with emphasis on chemistry, clinical trials being currently under investigation. Moreover, it is worth noting that methylene blue is the ancestor of modern anti-malaria drugs such as chloroquine and is associated to a lesser toxicity, the only drawback being a green-blue coloring of urine.

Following replication and sub-genomic RNA synthesis, the viral structural proteins S, E and M are translated and inserted into the endoplasmic reticulum (ER) for further processing by the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). After encapsidation of the viral genome by the N-proteins in the ERGIC, budding with viral structural proteins (first with M and E, then with S later on) leads to mature virions. Following assembly, virions are transported to the cell surface in vesicles for further release by exocytosis.

If some S-proteins remain outside the virions, they may also transit towards the surface for mediating cell-cell fusion between infected cells and adjacent uninfected cells, leading to giant multinucleated cells, responsible for virus spreading without detection or neutralization by virus-specific antibodies. Accordingly, the primary determinant for infection of a cell by coronaviruses is the attachment of the virion through non-covalent interactions of protein-S with a suitable receptor. For human coronaviruses it is known that HCoV-OC43 binds to N-acetyl-9-O-acetylneuraminic acid, HCoV-HKU1 binds to O-acetylated sialic acids, while HCoV-NL63 and SARS-CoV bind to heparin sulfate proteoglycans.5 After binding to the cell, coronaviruses use a broad variety of fusion receptors: aminopeptidase N (APN) for HCoV-229E, human leucocyte antigen molecule (HLA class I) or sialic acids for HCoV-OC43, angiotensin-converting enzyme 2 (ACE2) for HCoV-NL63 and SARS-CoVs and dipeptyl-peptidase (DPP4) for MERS-CoV. The binding receptor of HCoV-HKU1 remains unknown. ACE2 receptors are expressed by epithelial cells of the lung, intestine, kidney and blood vessels, with a substantial upregulation in patients with type 1 or 2 diabetes or hypertension, who are treated by ACE inhibitors and angiotensin II type-I receptor blockers (ARBs).6 Increased expression of ACE2 is also observed by thiazolinidiones and ibuprofen. It has thus been inferred that people using ACE2-stimulating drugs may have a higher risk of developing severe and fatal COVID-19.

Then the paper gets really medical sciency. But you can follow along somewhat, sometimes. Like the “don’t take ibuprofen right now” part. “cytokine storms” get mentioned several times, lots of chemical formulas and molecular drawings. Bottom line - I think - is that all of these drugs raise the pH in the body, and the virus can’t handle that at all.

All these malaria drugs are made to be synthetic quinine, because there really isn’t all that many chincona trees out there. The original “fever tree”. And you do get a very minor amount of quinine in tonic water, although if you happen to have some powdered chincona bark (Amazon) you can make your own, quite strong. Although too strong can mess you up, so ignore this idea if you’re smart. Kind of wondering if some of that and some zinc supplements might do the job? Actually, everybody else has wondered this already, which is why there isn’t a drop of it on shelves anywhere. And you’d have to drink gallons of it a day, as the pills are wonderfully concentrated.



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Oh, and just for the hell of it ... the idea of treating COVID with chloroquine has been out there, in the West, online, since early February for the general public. The West had the Chinese study results since January 25:

Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9Chloroquine is known to block virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10Our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoVinfection in Vero E6 cells(Fig.1c, d). Besides its antiviral activity, chloroquine has animmune-modulating activity, which may synergistically enhance its antiviral effect in vivo. Chloroquine is widely distributed in the whole body, including lung, after oral administration.

...

Our findings reveal that remdesivir and chloroquine are highly effective in the control of 2019-nCoV infection in vitro. Since these compounds have been used in human patients with a safety track record and shown to be effective against various ailments, we suggest that they should be assessed in human patients sufferingfrom the novel coronavirus disease.

this report was written by the coolest guy in China, Manli Wang. And Shi Zheng Li, both from the Wuhan Institute of Virology.

The USA had this information less than 10 days after there was just one known COVID-19 patient in the entire country. Just ONE. Link: the first known case was about 10 days after this report came out. Yes, at that point the threat was considered very low, but several US airports were already screening incoming passengers. On Trump’s watch. So “something was being done” even back then.

Posted by Drew458     on 04/08/2020 at 09:32 PM   
Filed Under: • Health-Medicine • pandemic and epidemic diseases •  
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