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calendar   Thursday - May 21, 2020

Hope Or Hype?

Two more positive news items today about the COVID. Rays of sunshine or blowing smoke? It’s hard to tell.

California biopharmaceutical company claims coronavirus antibody breakthrough

A California-based biopharmaceutical company claims to have discovered an antibody that could shield the human body from the coronavirus and flush it out of a person’s system within four days, Fox News has exclusively learned.

Later Friday, Sorrento Therapeutics will announce their discovery of the STI-1499 antibody, which the San Diego company said can provide “100% inhibition” of COVID-19, adding that a treatment could be available months before a vaccine hits the market.

“We want to emphasize there is a cure. There is a solution that works 100 percent,” Dr. Henry Ji, founder and CEO of Sorrento Therapeutics, told Fox News. “If we have the neutralizing antibody in your body, you don’t need the social distancing. You can open up a society without fear.”
...
Through their studies, Sorrento screened and tested billions of antibodies they have collected over the past decade. They say this made it possible to identify hundreds of potential antibody candidates that could successfully bind themselves to the spike proteins of the coronavirus. They found that a dozen of these antibodies demonstrated the ability to block the spike proteins from attaching itself to the human enzyme ACE2, which is the receptor a virus normally uses to enter human cells.

Through further testing, the researchers at Sorrento found that there was one particular antibody that showed to be 100 percent effective in blocking COVID-19 from infecting health cells — STI-1499.
...
Dr. Ji pointed out that the antibody can be used as preventative therapy since there are no side effects, and that it can be more effective than any vaccine that may be developed.

“This is the best solution,” he said. “The point of making a vaccine is to generalize a neutralizing antibody. So, if you already have one, you don’t need to the body to generate one from a vaccine. You’ve already provided it. You’re cutting out the middleman.”
...
“As soon as it is infused, that patient is now immune to the disease,” Dr. Brunswick said to Fox News. “For the length of time, the antibody is in that system. So, if we were approved [by the FDA] today, everyone who gets that antibody can go back to work and have no fear of catching COVID-19.”




US: $1.2 For 300 Million COVID vaccinations from UK. If it works.

U.S. commits $1.2 billion to possible British COVID vaccine
U.S. secures 300 million doses, almost a third, of potential AstraZeneca COVID-19 vaccine

The United States will pump up to $1.2 billion into developing AstraZeneca’s potential COVID-19 vaccine and said on Thursday it would order 300 million doses, as the White House seeks solutions to the coronavirus pandemic.

The commitment provides for a possible U.S.-based clinical trial this summer involving 30,000 volunteers and adds fuel to the British drugmaker’s efforts to develop a vaccine for the disease, one of around 100 which are under way worldwide.

U.S. Health and Human Services Secretary Alex Azar said he hoped the first doses of the vaccine, which is being developed with the University of Oxford in England, would be available by October, with the full order delivered by early in 2021.

However, AstraZeneca stressed that the vaccine may not work and that it was still waiting for results from an early stage trial in southern England, before any moves towards late stage testing.

The vaccine, previously known as ChAdOx1 nCoV-19 and now as AZD1222, was developed by the University of Oxford and licensed to British drugmaker AstraZeneca. Immunity to the new coronavirus is uncertain and so the use of vaccines unclear.

The U.S. deal allows a late-stage – Phase III – clinical trial of the vaccine with 30,000 people in the United States.

Should this thing work, AstraZeneca is gearing up to crank out a billion doses.

So, we’ve got the HCQ - Zinc - Zpack - Vitamin D treatment, the blood plasma treatment, at least one antibody fix that may be only a temporary cure, and at least one vaccine that’s effective enough so far to go to human trials.  That sounds hopeful to me. At one of the vaccine links I found, there’s a British doc in a video saying that the vaccine is easy to make and inexpensive. Sounds better than the $1000/pill for Remdesivir approach that might not work either.

I wonder what happened to that bunch down in Australia that said they had an antibody cure at least 12 weeks ago? Or the one from that research place up in Norway or Sweden?  The truth is, most of these approaches will fail. But the other truth is, putting the word out that you’ve come up with something can make the money come pouring in and the stock shoot right up.


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Posted by Drew458   United States  on 05/21/2020 at 07:00 PM   
Filed Under: • pandemic and epidemic diseases •  
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