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calendar   Thursday - March 19, 2020

As Expected, Trump Makes It Happen

President Trump: Move Forward With Plaquenil Right Now

President Trump announced Thursday that the Food and Drug Administration (FDA) is making experimental drugs—including those used for treating malaria -- available as part of the ongoing effort to tackle the spread of the coronavirus.

Trump announced at a White House press briefing that chloroquine, a drug designed for use in malaria, has been FDA approved and will be made available by prescription “almost immediately.” He said it was one of a number of antiviral therapies to limit the symptoms of the virus that the administration is trying to get to Americans as quickly as possible.

“I have directed the FDA to eliminate rules and bureaucracy so work can proceed rapidly, quickly and fast,” he said. “We have to remove every barrier.”

Addressing potential safety concerns, Trump noted that it had been used previously in treating malaria, “so we know if things don’t go as planned, it’s not going to kill anybody.” He said it had shown “very encouraging” early results.

He also said another drug, remdesivir, would be made available to Americans as well by the process of “compassionate use.” He said it would remain to be seen whether it would help combat the crisis.

So while the President did actually specifically say “chloroquine”, it’s pretty much a guarantee that he meant hydroxychloroquine sulfate, which is the common drug Plaquenil. To us laymen, it’s all chloroquine, although there are two forms of it, and the new NIH study did indicate that HCQ was much more effective. See yesterday’s posts.

U.S. researchers, following the lead of scientists in other countries, have launched studies to see whether widely-available, low-cost generic drugs can be used to help treat the illness caused by the new coronavirus.
...
... a 1,500-person trial, led by the University of Minnesota, began this week to see whether malaria treatment hydroxychloroquine can prevent or reduce the severity of COVID-19. Two other trials are studying the blood pressure drug losartan as a possible treatment for the disease.

The malaria drug, also being tested in China, Australia and France ...

Besides having a direct antiviral effect, hydroxychloroquine suppresses the production and release of proteins involved in the inflammatory complications of several viral diseases.

There was a report out of China recently that a test of 100 ailing subjects given Kaletra showed barely any positive effects (1 in 100), and bad reaction to that HIV medicine’s combination of lopinavir and ritonavir forced 13.8% off the mediction. Remdesivir is not the same as ritonavir.

This is most likely part of the WHO’s worldwide guinea pig large scale in-situ test of multiple solutions

The World Health Organization is taking the drug-testing approach that helped stifle Ebola’s latest resurgence and using it against the new coronavirus.

At least 10 countries including France, Spain and Switzerland agreed to join a trial called Solidarity that the global agency is coordinating, simultaneously testing four therapies by pitting them against each other.

The strategy is designed to speed up a process that can take years as doctors scour laboratories for promising treatments against the new virus.
...
In the Solidarity trials, researchers will test four therapies, some of which are already used in people, to treat Covid-19: Gilead Sciences Inc.’s experimental remdesivir, AbbVie Inc.’s Kaletra (used to treat HIV infection), Kaletra with an anti-inflammatory treatment called interferon-beta, and the malaria drug chloroquine.

China has included chloroquine in treatment recommendations for Covid-19. Ongoing studies showed that Kaletra, a combination of the drugs lopinavir and ritonavir, gave little benefit, according to early results published Wednesday in the New England Journal of Medicine. Additional medicines may be added and some of the original treatments may be cut out as the trial progresses.

https://townhall.com/tipsheet/leahbarkoukis/2020/03/19/fox-interview-malaria-drug-to-treat-n2565260


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Posted by Drew458   United States  on 03/19/2020 at 12:06 PM   
Filed Under: • Health-Medicinepandemic and epidemic diseases •  
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